Z2626

Zaragozic acid A trisodium salt

from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor

• Synonyme(s) : L-694,599, Squalestatin
• Formule empirique (notation de Hill) : C₃₅H₄₃O₁₄Na₃
• CAS Number: 144541-82-2
• Poids moléculaire : 756.68
• Numéro MDL: MFCD03788025
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
• Source biologique: microbial
• Niveau de qualité: 200
• Essai: ≥95% (HPLC)
• Forme: lyophilized powder
• Solubilité: DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• Conditions d'expédition: wet ice
• Température de stockage: −20°C

Description

Application

Zaragozic acid A trisodium salt has been used as:

• a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
• a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
• a cholesterol synthesis inhibitor in T cells

Actions biochimiques/physiologiques

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

Informations légales

Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)