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475870

Sigma-Aldrich

MnTBAP

≥95% (TLC), solid, SOD mimetic, Calbiochem®

Synonym(s):

MnTBAP, Mn(III)tetrakis(4-benzoic acid)porphyrin Chloride

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About This Item

Empirical Formula (Hill Notation):
C48H28ClMnN4O8
CAS Number:
Molecular Weight:
879.15
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

MnTBAP, Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.

Quality Level

Assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

brown

solubility

aqueous base: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

[Mn]1([n]2c3c(c5nc(c(c7[n]1c(c(c9nc(c(c2cc3)c%10ccc(cc%10)C(=O)O)cc9)c8ccc(cc8)C(=O)O)cc7)c6ccc(cc6)C(=O)O)cc5)c4ccc(cc4)C(=O)O)Cl

InChI key

XHVDAQLNUQLQKW-PTJHDCLZSA-K

General description

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).

Biochem/physiol Actions

Cell permeable: yes
EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)
Primary Target
Superoxide dismutase (SOD) mimetic
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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