475870

MnTBAP

≥95% (TLC), solid, SOD mimetic, Calbiochem^®

• Synonym(s): MnTBAP, Mn(III)tetrakis(4-benzoic acid)porphyrin Chloride
• Empirical Formula (Hill Notation): C₄₈H₂₈ClMnN₄O₈
• CAS Number: 55266-18-7
• Molecular Weight: 879.15
• MDL number: MFCD06227760
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: MnTBAP, Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
• Quality Level: 100
• Assay: ≥95% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated; protect from light
• color: brown
• solubility: aqueous base: soluble
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [Mn]1([n]2c3c(c5nc(c(c7[n]1c(c(c9nc(c(c2cc3)c%10ccc(cc%10)C(=O)O)cc9)c8ccc(cc8)C(=O)O)cc7)c6ccc(cc6)C(=O)O)cc5)c4ccc(cc4)C(=O)O)Cl
• InChI key: XHVDAQLNUQLQKW-PTJHDCLZSA-K

Description

General description

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC₅₀ ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).

Biochem/physiol Actions

Cell permeable: yes

EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)

Primary Target
Superoxide dismutase (SOD) mimetic

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable