A1757

6-Azauracil

≥98%

• Synonym(s): 6-AU, 1,2,4-Triazine-3,5(2H,4H)-dione, 3,5-Dihydroxy-1,2,4-triazine, 6-Aza-2,4-dihydroxypyrimidine
• Empirical Formula (Hill Notation): C₃H₃N₃O₂
• CAS Number: 461-89-2
• Molecular Weight: 113.07
• Beilstein: 116472
• EC Number: 207-318-0
• MDL number: MFCD00006456
• UNSPSC Code: 41106305
• PubChem Substance ID: 24890584
• NACRES: NA.51

Properties

• Quality Level: 100
• Assay: ≥98%
• form: powder
• mp: 274-275 °C (lit.)
• solubility: 1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green
• SMILES string: O=C1NN=CC(=O)N1
• InChI: 1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
• InChI key: SSPYSWLZOPCOLO-UHFFFAOYSA-N

Description

Application

6-Azauracil has been used as a transcriptional inhibitor to study its effects on the deletion of termination and polyadenylation protein (Tpa1) and Mag1 on cell viability. It has also been used as an orotidine-5′-monophosphate decarboxylase (OMPdecase) inhibitor in minimal media for determining the OMPdecase activity.

Biochem/physiol Actions

6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity. It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP) and uridine triphosphate (UTP) nucleotide pools.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves