D122

Domperidone

powder, ≥98% (HPLC)

• Synonym(s): 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine
• Empirical Formula (Hill Notation): C₂₂H₂₄ClN₅O₂
• CAS Number: 57808-66-9
• Molecular Weight: 425.91
• EC Number: 260-968-7
• MDL number: MFCD00069256
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277911
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >10 mg/mL; 0.1 M HCl: soluble; 0.1 M NaOH: slightly soluble; H₂O: insoluble
• originator: Johnson & Johnson
• SMILES string: Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1
• InChI: 1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
• InChI key: FGXWKSZFVQUSTL-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), KCNH2(3757) ; rat ... Drd1a(24316), Drd2(24318), Drd3(29238), Htr3a(79246)

Description

Biochem/physiol Actions

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Statements: H361fd
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves