E8750

α-Estradiol

powder, ≥98% (TLC)

• Synonym(s): 1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol
• Empirical Formula (Hill Notation): C₁₈H₂₄O₂
• CAS Number: 57-91-0
• Molecular Weight: 272.38
• EC Number: 200-354-8
• MDL number: MFCD00064144
• UNSPSC Code: 12352200
• PubChem Substance ID: 24894682
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥98% (TLC)
• form: powder
• color: white to slight yellow
• solubility: ethanol: 50 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
• InChI key: VOXZDWNPVJITMN-SFFUCWETSA-N
• Gene Information: human ... ESR1(2099), ESR2(2100) ; rat ... Ar(24208)

Description

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.

Safety Information

• Pictograms: GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H341,H351,H360F,H362,H410
• Precautionary Statements: P202 - P260 - P263 - P264 - P273 - P308 + P313
• Hazard Classifications: Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves