F5130

5-Fluorouridine

proapoptotic anitproliferative plant growth regulator

• Synonym(s): 5-Fluorouracil 1β-D-ribofuranoside, FUrd
• Empirical Formula (Hill Notation): C₉H₁₁FN₂O₆
• CAS Number: 316-46-1
• Molecular Weight: 262.19
• Beilstein: 33662
• EC Number: 206-260-3
• MDL number: MFCD00036832
• UNSPSC Code: 41106305
• PubChem Substance ID: 24894883
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Quality Level: 100
• Assay: ≥99% (HPLC)
• form: powder
• solubility: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O
• InChI: 1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
• InChI key: FHIDNBAQOFJWCA-UAKXSSHOSA-N

Description

General description

5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.

Application

5-Fluorouridine has been used for labeling active transcription sites in the porcine fetal fibroblasts and human cell lines for immunocytochemistry analysis. It has also been used to monitor apoptosis during drug sensitivity assay in esophageal squamous cell carcinoma (ESCC) cells.

Biochem/physiol Actions

5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves