H3023

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid

≥90% (HPLC), liquid, Ras/MAP pathway activitor

• Synonym(s): 20-HETE, 20-Hydroxyarachidonic acid
• Empirical Formula (Hill Notation): C₂₀H₃₂O₃
• CAS Number: 79551-86-3
• Molecular Weight: 320.47
• MDL number: MFCD00171542
• UNSPSC Code: 12352106
• PubChem Substance ID: 24895546
• NACRES: NA.77

Properties

• Product Name: 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid, ~100 μg/mL in ethanol, ≥90% (HPLC)
• Quality Level: 200
• Assay: ≥90% (HPLC)
• form: liquid
• concentration: ~100 μg/mL in ethanol
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: OCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
• InChI: 1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-
• InChI key: NNDIXBJHNLFJJP-DTLRTWKJSA-N

Description

Biochem/physiol Actions

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid (20-HETE) is an arachidonic acid metabolite via cytochrome P4504A, that is an activator of the Ras/MAP (microtubule-associated protein) pathway. 20-HETE acid is a predominant arachidonic acid present in the kidney. It is involved in the regulation of sodium, potassium and chloride transport in the renal tubules. 20-HETE is often excreted in urine in the form of glucuronide conjugate and sometimes as free acids. Increased urine 20-HETE is observed during pregnancy in rats.

Packaging

Packaged under argon.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H319
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 57.2 °F - closed cup
• Flash Point(C): 14.0 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves