H6649

Herbimycin A from Streptomyces hygroscopicus

≥95% (HPLC), powder

• Empirical Formula (Hill Notation): C₃₀H₄₂N₂O₉
• CAS Number: 70563-58-5
• Molecular Weight: 574.66
• Beilstein: 4834067
• MDL number: MFCD00151702
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895756
• NACRES: NA.77

Properties

• biological source: Streptomyces hygroscopicus
• Quality Level: 200
• Assay: ≥95% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: 7.5 mg/mL
• antibiotic activity spectrum: viruses
• Mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
• InChI: 1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
• InChI key: MCAHMSDENAOJFZ-BVXDHVRPSA-N

Description

General description

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

Biochem/physiol Actions

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.

Caution

Hygroscopic and photosensitive

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves