N7502

DL-Norvaline

≥98% (HPLC), suitable for HPLC

• Synonym(s): (±)-2-Aminopentanoic acid
• Linear Formula: CH₃CH₂CH₂CH(NH₂)COOH
• CAS Number: 760-78-1
• Molecular Weight: 117.15
• Beilstein: 1721163
• EC Number: 212-082-7
• MDL number: MFCD00064420
• UNSPSC Code: 12352209
• PubChem Substance ID: 24897829
• NACRES: NA.26

Properties

• Product Name: DL-Norvaline,
• Assay: ≥98% (HPLC)
• Quality Level: 200
• form: powder
• technique(s): HPLC: suitable
• color: white
• mp: >300 °C
• SMILES string: CCCC(N)C(O)=O
• InChI: 1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)
• InChI key: SNDPXSYFESPGGJ-UHFFFAOYSA-N

Description

General description

Norvaline is a non-proteinogenic α-amino acid and is also called DL-α-aminovaleric acid. It is produced in Gram-negative microorganisms including Escherichia coli and is also a part of the antifungal peptide produced by Bacillus subtilis.

Application

DL-Norvaline has been used as an internal standard:

• to analyze metabolites in cultured mammalian cells by gas chromatography-mass spectrometry (GC-MS)
• to convert cysteine and cystine to Cys MPA (S-2-carboxyethylthio-L-cysteine) and quantify the same using a high-performance liquid chromatography (HPLC) analyzer
• for free amino acid analysis in samples of oocytes by liquid chromatography

Biochem/physiol Actions

DL-Norvaline is a neurotransmitter.

Norvaline mediates physiological and pathophysiological processes promoting nitric oxide production. It is used to treat Alzheimer′s disease and is effective against artificial metabolic syndrome in rats. Norvaline exhibits phase transition upon cooling below 190 K and hence it is useful in molecular machines. DL-Norvaline serves as a prototype for research in polymorphism and molecular dynamics of aliphatic α-amino acids containing linear side-chain. It influences the activity, stability, and side-chain packaging of proteins.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves