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S5826

Sigma-Aldrich

SYUIQ-5

≥98% (HPLC)

Synonym(s):

N′-(10H-Indolo [3,2-b]quinolin-11-yl)-N, N-dimethyl-propane-1,3-diamine

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5 MG
CA$804.00

About This Item

Empirical Formula (Hill Notation):
C20H22N4
CAS Number:
Molecular Weight:
318.42
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

CA$804.00


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Quality Level

Assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

CN(C)CCCNc1c2ccccc2nc3c4ccccc4[nH]c13

InChI

1S/C20H22N4/c1-24(2)13-7-12-21-18-14-8-3-5-10-16(14)22-19-15-9-4-6-11-17(15)23-20(18)19/h3-6,8-11,23H,7,12-13H2,1-2H3,(H,21,22)

InChI key

CTDCVGDSVHUYMA-UHFFFAOYSA-N

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This Item
SML1886SML2342SML0796
SYUIQ-5 ≥98% (HPLC)

S5826

SYUIQ-5

SGC3027N ≥98% (HPLC)

SML2342

SGC3027N

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 3 mg/mL, clear (warmed)

color

yellow

color

white to beige

color

white to beige

color

orange to dark red

Application

SYUIQ-5 may be used in autophagy and DNA damage-inducing cell signaling studies.

Biochem/physiol Actions

G-quadruplex stabilizer; induces authophagy in cancer cells.
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.

Pictograms

Environment

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Acute 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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