SML1930

CORM-401

• Synonym(s): Mn(CO)4{S2CNMe(CH2CO2H)}, Tetracarbonyl[N-(dithiocarboxy-?S,?S′)-N-methylglycine]manganate
• Empirical Formula (Hill Notation): C₈H₆MnNO₆S₂
• CAS Number: 1001015-18-4
• Molecular Weight: 331.20
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 100
• storage condition: protect from light
• color: light yellow to dark yellow
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CN(CC(O)=O)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1

Description

Biochem/physiol Actions

CORM-401 (Mn(CO)4(S2CNMe(CH2CO2H))) is a manganese-containing carbon monoxide-releasing molecule (CORM) that generates at least three molar equivalents of CO. Due to reversible binding of CO, CORM-401 is relatively stable in solution (0.33 mol eq of CO loss after 4 h in PBS; [CORM-401] = 1 mM at time zero), while increased CO release occurs in the presence of a CO receptor or a ligand to prevent the rebinding of CO (3.2 mol eq of CO transferred to iron with a t1/2 of 0.8 min in the presence of 44 μM myoglobin; [CORM-401] = 10 μM at time zero). CO administration by CORM-401 is reported to uncouple mitochondrial respiration and inhibit glycolysis in human endothelial cells (10-100 μM), and relax isolated rat aortic rings (25 μM) pre-contracted with phenylephrine.

Mn-containing carbon monoxide-releasing molecule (CORM) that generates three-times more CO than CORM-A1 and CORM-3.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3