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SML3030

Sigma-Aldrich

Atorvastatin calcium salt trihydrate

≥98% (HPLC)

Synonym(s):

(betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoate, calcium salt (2:1) trihyddrate, [R-(R*, R*)]-2-(4-Fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1Hpyrrole-1-heptanoic acid, calcium salt (2:1) trihydrate

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About This Item

Empirical Formula (Hill Notation):
C66H68F2N4O10 · Ca · 3H2O
CAS Number:
Molecular Weight:
1209.39
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -9.0 to -5.0°, c = 0.5 in DMSO

storage condition

protect from light

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

O=C(C1=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C2=CC=C(C=C2)F)=C1C3=CC=CC=C3)NC4=CC=CC=C4.[Ca+2].[3.0H2O]

InChI

1S/2C33H35FN2O5.Ca.3H2O/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;3*1H2/q;;+2;;;/p-2/t2*26-,27-;;;;/m11..../s1

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This Item
725226717274B33803
assay

95%

assay

99%

assay

97%

assay

98%

refractive index

n20/D 1.495 (lit.)

refractive index

n20/D 1.486 (lit.)

refractive index

-

refractive index

n20/D 1.470 (lit.)

bp

81-82 °C/10 mmHg (lit.)

bp

225 °C (lit.)

bp

-

bp

89 °C (lit.)

density

1.067 g/mL at 20 °C (lit.)

density

0.981 g/mL at 25 °C (lit.)

density

-

density

0.906 g/mL at 25 °C (lit.)

Biochem/physiol Actions

β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase inhibitor.
Atorvastatin calcium salt trihydrate is a specific inhibitor of β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Atorvastatin is used in the treatment of hypercholesterolemia.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Franziska Curdt et al.
Optics express, 23(24), 30891-30903 (2015-12-25)
Despite the need for isotropic optical resolution in a growing number of applications, the majority of super-resolution fluorescence microscopy setups still do not attain an axial resolution comparable to that in the lateral dimensions. Three-dimensional (3D) nanoscopy implementations that employ
Erdinc Sezgin et al.
Journal of lipid research, 57(2), 299-309 (2015-12-25)
Cholesterol (Chol) is a crucial component of cellular membranes, but knowledge of its intracellular dynamics is scarce. Thus, it is of utmost interest to develop tools for visualization of Chol organization and dynamics in cells and tissues. For this purpose
Daniel Neumann et al.
PMC biophysics, 3(1), 4-4 (2010-03-09)
The voltage-dependent anion channel (VDAC, also known as mitochondrial porin) is the major transport channel mediating the transport of metabolites, including ATP, across the mitochondrial outer membrane. Biochemical data demonstrate the binding of the cytosolic protein hexokinase-I to VDAC, facilitating
Christian Kukat et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(33), 13534-13539 (2011-08-03)
Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial biology and will determine tissue segregation and transmission of mtDNA. We have used a combination of stimulated emission
Roman Schmidt et al.
Nano letters, 9(6), 2508-2510 (2009-05-23)
Because of the diffraction resolution barrier, optical microscopes have so far failed in visualizing the mitochondrial cristae, that is, the folds of the inner membrane of this 200 to 400 nm diameter sized tubular organelle. Realizing a approximately 30 nm

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