SRP5162
4EBP1, His tagged human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
BP-1, EIF4EBP1, MGC4316, PHAS-I
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250 G
₹7,535.00
About This Item
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biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~18 kDa
NCBI accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... EIF4EBP1(1978)
1 of 4
This Item | 86216 | P2443 | 713538 |
|---|---|---|---|
| application(s) detection | application(s) - | application(s) - | application(s) - |
| Quality Level 100 | Quality Level - | Quality Level 200 | Quality Level 100 |
| impurities ≤0.5% water | impurities ≤1.0% water | impurities - | impurities ≤1.0% water |
| mp 56-61 °C | mp 40-50 °C | mp - | mp - |
| hydroxyl value 6‑9 mg KOH/g | hydroxyl value 15‑19 mg | hydroxyl value - | hydroxyl value - |
General description
Biochem/physiol Actions
Eukaryotic translation initiation factor 4E binding protein 1 (E1F4EBP1) is involved in protein synthesis, cell growth and survival. In the unphosphorylated form, it suppresses the translation initiation of capped mRNAs, whereas in phosphorylated form, it increases translation initiation. Phosphorylation of E1F4EBP1 releases it from eukaryotic translation initiation factor 4E (eIF4E) and this results in cap-dependent translation. The protein is also involved in tumorigenesis and the gene is overexpressed in various carcinomas. It is also a substrate for mTORC1 (mammalian target of rapamycin complex 1). In non-phosphorylated conditions, E1F4EBP1 interacts with p21 (cyclin-dependent kinase inhibitor) and enhances destabilization of p21.[3][1][4]
Physical form
Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
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