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SRP5205

Sigma-Aldrich

MBP, GST tagged human

recombinant, expressed in E. coli, ≥65% (SDS-PAGE), buffered aqueous glycerol solution

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About This Item

CAS Number:
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥65% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~36 kDa

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MBP(4155)

General description

Myelin basic protein (MBP), an important constituent of the myelin sheath of CNS (central nervous system), is an autoimmunogen. It is mapped to human chromosome 18q.

Biochem/physiol Actions

MBP or Myelin basic protein forms dimers across the cytoplasmic apposition during the formation of myelin. The region of the protein involved in folding, polymerization and substrate specificities is conserved in various species and it may have a specialized role in protein-lipid interactions in the myelin membrane. MBP is an efficient substrate for numerous protein kinases and share similarities with the MARCKS protein in terms of having extended conformations regulated by their environment, N-terminal modifications, a dual nature of interactions with lipids, and binding to actin and Ca2+-calmodulin. Myelin basic protein (MBP) is expected to play a vital role in demyelinating diseases such as MS (multiple sclerosis).

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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