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T1157

Sigma-Aldrich

(+)-α-Tocopherol acetate

BioReagent, suitable for insect cell culture, ~1360 IU/g

Synonym(s):

Vitamin E acetate

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1 G
₹2,365.00
10 G
₹5,412.00

About This Item

Empirical Formula (Hill Notation):
C31H52O3
CAS Number:
58-95-7
Molecular Weight:
472.74
EC Number:
200-405-4
MDL number:
MFCD00072052
UNSPSC Code:
12352205
eCl@ss:
34058007
PubChem Substance ID:
24899940
NACRES:
NA.75

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biological source

plant

Quality Level

200

description

Synthesized from natural α-tocopherol

product line

BioReagent

form

liquid (or semi-solid)

specific activity

~1360 IU/g

mol wt

Mw 472.74 g/mol

purified by

crystallization

technique(s)

cell culture | insect: suitable

color

white to yellow

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This Item
T300129992T1539
(+)-α-Tocopherol acetate BioReagent, suitable for insect cell culture, ~1360 IU/g

T1157

(+)-α-Tocopherol acetate

(+)-α-Tocopherol acetate oil or semi-solid, ~1360 IU/g

T3001

(+)-α-Tocopherol acetate

DL-α-Tocopherol acetate tested according to Ph. Eur.

29992

DL-α-Tocopherol acetate

(+)-α-Tocopherol Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g

T1539

(+)-α-Tocopherol

technique(s)

cell culture | insect: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | insect: suitable

biological source

plant

biological source

plant

biological source

synthetic

biological source

vegetable oil

form

liquid (or semi-solid)

form

oil or semi-solid

form

liquid

form

liquid (≥0.88M based on potency, density and molecular wt.)

solubility

chloroform: soluble 50 mg/mL, clear, colorless to yellow

solubility

-

solubility

-

solubility

chloroform: soluble 0.1 mL/mL, clear, faintly yellow to yellow

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

color

white to yellow

color

yellow

color

-

color

yellow-orange

General description

α-Tocopherol acetate is a semisynthetic acetate ester of naturally occurring α-tocopherol.

Application

(+)-α-Tocopherol acetate has been used:
  • as a supplement in the human embryonic kidney cells (HEK 293) to assess its impact on cell growth[1]
  • as a component of Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12) for immortalized chondrocyte cell line[2]
  • as a component of serum-free medium for human colon tissue organ culture[3]
  • to test its antioxidant effects on cow articular chondrocytes[4]

Use in insect cell culture applications as an antioxidant.

Biochem/physiol Actions

α-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation.[5] However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.[6]

Caution

Since the M.P. is about 25 °C this preparation is usually an oil. Does not air oxidize.

Hazard Statements

H413

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCL1318
    SLCH1778
    SLBZ9611
    SLBZ4654
    SLBX4005

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    Michael K Dame et al.
    In vitro cellular & developmental biology. Animal, 46(2), 114-122 (2009-11-17)
    Normal and neoplastic human colon tissue obtained at surgery was used to establish conditions for organ culture. Optimal conditions included an atmosphere of 5% CO2 and 95% O2; tissue partially submerged with mucosa at the gas interface; and serum-free medium
    Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.
    Laura Cervera et al.
    BMC proceedings, 5 Suppl 8, P126-P126 (2012-03-01)
    Michael K Dame et al.
    In vitro cellular & developmental biology. Animal, 47(1), 32-38 (2010-11-26)
    We have recently shown that a multi-mineral extract from the marine red algae, Lithothamnion calcareum, suppresses colon polyp formation and inflammation in mice. In the present study, we used intact human colon tissue in organ culture to compare responses initiated
    Dan Wu et al.
    Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6349-6355 (2020-03-12)
    A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in pulmonary injuries associated with using
    Brandon Mapes et al.
    Physiological genomics, 46(8), 302-308 (2014-02-20)
    1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3] is a steroid hormone derived from circulating 25(OH) vitamin D [25(OH)D] with chemopreventive effects in colorectal cancer. 1α,25(OH)2D3 acts through transcriptional mechanisms; however, our understanding of vitamin D transcriptional responses in the colon is derived from studies
    View All Related Papers

    Articles

    Vitamin E, Tocopherol, in Cell Culture

    Importance and uses of vitamin E (tocopherol) in serum-free eukaryotic, including hybridoma and chinese hamster ovary (CHO), cell cultures.

    Dietary Antioxidants

    Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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