P8783

Progesterone

powder, BioReagent, suitable for cell culture

• Sinonimo/i: 4-Pregnene-3,20-dione
• Formula empirica (notazione di Hill): C₂₁H₃₀O₂
• CAS Number: 57-83-0
• Peso molecolare: 314.46
• Beilstein: 1915950
• Numero CE: 200-350-6
• Numero MDL: MFCD00003658
• Codice UNSPSC: 12352209
• ID PubChem: 24898978
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Descrizione: synthesized from materials derived from plant source
• Nome Commerciale: BioReagent
• Saggio: ≥99%
• Stato: powder
• Potenza: 0.1-20 ng/mL
• tecniche: cell culture | mammalian: suitable
• Punto di fusione: 128-132 °C (lit.)
• Solubilità: absolute ethanol: 1 mg/mL
• Temperatura di conservazione: room temp
• Stringa SMILE: CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1; RJKFOVLPORLFTN-LEKSSAKUSA-N
• Informazioni sul gene: human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

Descrizione

Descrizione generale

Progesterone is a steroid hormone secreted by the ovaries.

Applicazioni

Progesterone has been used:

• as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
• to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
• as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Azioni biochim/fisiol

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Altre note

Steroid hormone produced by the corpus luteum.

Stato fisico

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Ricostituzione

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H351,H360FD,H362
• Consigli di prudenza: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Classi di pericolo: Carc. 2 - Lact. - Repr. 1A
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges