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CAR-213

Sigma-Aldrich

Cardiolipin Liposomes

PC:CL (10:90 molar ratio 10mM)

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5 ML
609,00 $
25 ML
2 020,00 $

609,00 $


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5 ML
609,00 $
25 ML
2 020,00 $

About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

609,00 $


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Quality Level

composition

Phosphate buffered saline

concentration

10 mM

impurities

10 mol % L-alpha-phosphatidylcholine (PC)
90 mol % Cardiolipin (CL)

particle size

100 nm

pH

7.4

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This Item
794167940879417
concentration

~0.8 M in hexane

concentration

~2.0 M in THF

concentration

-

concentration

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

liquid

form

solution

form

liquid

form

liquid

density

0.850-0.875 g/mL at 20 °C

density

-

density

-

density

1.02 g/mL at at 25 °C (lit.), 1.02 g/mL at 25 °C (lit.)

functional group

amine

functional group

amine

functional group

amine

functional group

amine

General description

Liposomes are extensively used to study the interaction of proteins, peptides and other molecules with the surface of a lipid membrane.

Cardiolipin (CL) is a unique phospholipid with an interesting chemical and ultrastructural characteristics. It is a highly acidic dimer of phosphatidylglycerol (PG) and phosphatidic acid (PA) containing four acyl chains, three glycerols and two phosphate headgroups. Due to deprotonation of one of these phosphate groups, cardiolipin is negatively charged in physiological pH.

Cardiolipin (CL) is known as a mitochondria-specific phospholipid and is intimately linked to mitochondrial bioenergetic processes. It plays a functional role in mitochondrial membrane stability and dynamics, as it interacts with a number of inner mitochondrial membrane metabolite carriers, enzymes and proteins. Extensive studies of phamacological, toxicological, and therapeutic effects have shown that the incorporation of doxorubicin in cardiolipin liposomes improved antitumor activity. It has been reported that cardiolipin-containing liposomes have lower cardiotoxicity associated with doxorubicin by alteriing the pharmacokinetics and tissue distribution of the drug.

Cardiolipin is a negatively charged lipid and provides two types of binding possibilities: binding at the surface and encapsulation deep within the membrane. Our catalog of cardiolipin lipids contains many different types of saturated and unsaturated cardiolipin based liposomes made from 0.5% up to 100% cardiolipin.

Application

Drug delivery
Lipid-protein interactions

Storage and Stability

Liposomes should never be frozen. Liposomes should be stored in the dark at 4°C, except when brought to room temperature for brief periods prior to use.

Liposomes are made under sterile conditions. If you need to take multiple aliquots out of the vial, it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size of liposomes particles.

Legal Information

Cellsome is a trademark of Encapsula NanoSciences
Product of Encapsula Nanosciences

Disclaimer

For research use only

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.
Harris N L E, et al.
Oncogene, 36(30), 4288-4288 (2017)
John H Rossmeisl et al.
OncoTargets and therapy, 10, 2077-2085 (2017-04-27)
The expression of the urokinase plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol-anchored protein family member, and the activity of its ligand, urokinase-type plasminogen activator (uPA), have been associated with the invasive and metastatic potentials of a variety of human brain tumors
Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children.
Schaefer F, et al.
JAMA Pediatrics, 171(11), e172914-e172914 (2017)
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
Chang H Y, et al.
PLoS Biology, 2(2), 7-7 (2004)
Yue Lang et al.
Cell death & disease, 10(6), 401-401 (2019-05-28)
Urokinase plasminogen activator receptor (uPAR) is upregulated in podocytes of glomerular diseases and crucially mediates podocyte injury through integrin β3 (ITGB3). We previously showed that the miR-30 family maintains podocyte structure and function by inhibiting injurious calcineurin signaling through nuclear

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