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SAB1410147

Sigma-Aldrich

Anti-RAB32 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

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₹9,760.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

₹9,760.00

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 24.75 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

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1 of 4

This Item
933971659568.21197
Tetrabenzyl pyrophosphate 98%

418633

Tetrabenzyl pyrophosphate

Tris(tetrabutylammonium) hydrogen pyrophosphate ≥97.0% (calc. on dry substance, T)

93397

Tris(tetrabutylammonium) hydrogen pyrophosphate

Methyl benzenesulfonate 98%

165956

Methyl benzenesulfonate

Triphenyl phosphate for synthesis

8.21197

Triphenyl phosphate

assay

98%

assay

≥97.0% (calc. on dry substance, T)

assay

98%

assay

≥99.0% (GC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

mp

63-66 °C (lit.)

mp

-

mp

-

mp

48-50 °C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

functional group

phenyl

functional group

amine, phosphate

functional group

sulfonic acid

functional group

-

General description

Small GTP-binding proteins of the RAB family, such as RAB32, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM

Immunogen

RAB32 (NP_006825.1, 1 a.a. ~ 225 a.a) full-length human protein.

Sequence
MAGGGAGDPGLGAAAAPAPETREHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVLNWDSRTLVRLQLWDIAGQERFGNMTRVYYKEAVGAFVVFDISRSSTFEAVLKWKSDLDSKVHLPNGSPIPAVLLANKCDQNKDSSQSPSQVDQFCKEHGFAGWFETSAKDNINIEEAARFLVEKILVNHQSFPNEENDVDKIKLDQETLRAENKSQCC

Biochem/physiol Actions

RAB32 (Ras-related protein) controls intracellular lipid accumulation in hepatocytes. Absence of it promotes the expression of ATGL (adipose triglyceride lipase) and thereby causes lipolysis. RAB32 is involved in hepatic steatosis. In melanogenesis, it is involved in the transport of important enzymes, such as tyrosinase and Tyrp1 (tyrosinase related protein 1). RAB32 also interacts with and is involved in localization of leucine-rich repeat kinase 2 (LRRK2), a protein associated with Parkinson′s disease. RAB32 is hypermethylated in microsatellite-unstable colon, gastric and endometrial adenocarcinomas.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    09040

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    Solvolysis of Tetrabenzyl Pyrophosphate. Catalysis by Imidazole1
    Blakeley R, et al.
    Journal of the American Chemical Society, 88(1), 112-119 (1966)
    Journal of the Chemical Society. Perkin Transactions 1, 729-729 (1992)
    D Xu et al.
    Talanta, 51(2), 365-371 (2008-10-31)
    Tetrabenzyl pyrophosphate and diphenylphosphinic anhydride, with two phosphoryl groups (PO) as ligating sites, can be used as novel ionophores to make Pb(2+)-selective membrane electrodes. A good result was obtained with tetrabenzyl pyrophosphate, and the electrode based on this ionophore and
    N S Utkina et al.
    Bioorganicheskaia khimiia, 15(10), 1375-1383 (1989-10-01)
    Interaction of lithium alcoholates of 2,4-di-O-benzoates of paratose and abequose with tetrabenzyl pyrophosphate gave alpha-phosphates of the 3,6-dideoxyhexoses, further converted into the corresponding cytidine-5'-diphosphate derivatives. These synthetic nucleotides were shown to participate in the biosynthesis of the O-specific polysaccharides for
    Eranthie Weerapana et al.
    Journal of the American Chemical Society, 127(40), 13766-13767 (2005-10-06)
    The chemical synthesis and biological activity of undecaprenyl pyrophosphate bacillosamine (Und-PP-Bac), an obligatory intermediate in the asparagine-linked glycosylation pathway of Campylobacter jejuni, are reported. The key transformation involves the coupling of bacillosamine phosphate and undecaprenyl phosphate. The synthetic Und-PP-Bac can
    View All Related Papers

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