748684

Phosgene solution

15 wt. % in toluene

• 동의어(들): Carbon oxychloride, Carbonyl chloride, Phosgen
• Linear Formula: COCl₂
• CAS Number: 75-44-5
• Molecular Weight: 98.92
• Beilstein: 1098367
• MDL number: MFCD00036119
• UNSPSC 코드: 12352101
• PubChem Substance ID: 329765925
• NACRES: NA.22

속성

• 양식: liquid
• Quality Level: 200
• 농도: 15 wt. % in toluene
• density: 0.924 g/mL at 25 °C
• 작용기: chloro
• 저장 온도: 2-8°C
• SMILES string: ClC(Cl)=O
• InChI: 1S/CCl2O/c2-1(3)4
• InChI key: YGYAWVDWMABLBF-UHFFFAOYSA-N

설명

일반 설명

Phosgene is used as a reagent in organic synthesis for various reactions such as carbonylation reaction and synthesis of isocyanates. Phosgene is formed during the free radical induced degradation of chlorinated hydrocarbons. Determination of phosgene in air samples using thermal desorption (TD) followed by gas chromatography-mass spectrometry (GC-MS) has been reported.

애플리케이션

Phosgene solution (15 wt. % in toluene) has been used to synthesize the following peptide monomers:

• γ-(4-propargyloxybenzyl)-L-glutamic acid N-carboxyanhydride (POB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate N-carboxyanhydride (DMNB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-D-glutamate N-carboxyanhydride (DMNB-D-Glu-NCA)
• 2-nitrobenzyl(4-vinylphenyl)carbamate

Phosgene solution may be used in the synthesis of:

• sulfonyl chlorides
• Fmoc (Fluorenylmethyloxycarbonyl chloride)-taurylsulfonyl chloride
• O-benzyl-L-serine carboxyanhydrides

포장

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

법적 정보

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H225,H304,H314,H330,H336,H361d,H373,H412
• 예방조치 성명서: P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT RE 2 - STOT SE 3
• 표적 기관: Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point (°F): 39.2 °F - closed cup
• Flash Point (°C): 4 °C - closed cup