909998

2-(2-((7-(tert-Butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid

≥95%

• 동의어(들): 2-2-6 PROTAC^® linker, Bifunctional linker, OtBu-PEG₂-acid
• 실험식(Hill 표기법): C₁₅H₂₈O₆
• Molecular Weight: 304.38
• UNSPSC 코드: 12352200

속성

• 분석: ≥95%
• 양식: liquid
• 반응 적합성: reagent type: linker
• 작용기: carboxylic acid; ester
• 저장 온도: 2-8°C
• SMILES string: CC(C)(OC(CCCCCCOCCOCC(O)=O)=O)C

설명

애플리케이션

This heterobifunctional, PEGylated crosslinker 2-(2-((7-(tert-butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

기타 정보

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable