910058

2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid

≥95%

• 동의어(들): 2-2-6 PROTAC^® linker, Alkyne-PEG₂-acid, Bifunctional linker
• 실험식(Hill 표기법): C₁₂H₂₀O₄
• Molecular Weight: 228.28
• UNSPSC 코드: 12352106

속성

• 분석: ≥95%
• 양식: (Viscous Liquid or Semi-solid or Paste or Solid)
• 반응 적합성: reaction type: click chemistry; reagent type: linker
• 작용기: alkyne; carboxylic acid
• 저장 온도: 2-8°C
• SMILES string: OC(COCCOCCCCCCC#C)=O

설명

애플리케이션

This heterobifunctional, PEGylated crosslinker 2-(2-(oct-7-yn-1-yloxy)ethoxy)acetic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₂-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

기타 정보

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable