917710

A1V1PF2-OEt

≥95%

• 동의어(들): AVP ligand, Ethyl (S)-2-((S)-1-((S)-2-((S)-2-aminopropanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoate, IAP E3 ligase lead for protein degrader research, SNIPER building block
• 실험식(Hill 표기법): C₂₅H₃₇FN₄O₅
• Molecular Weight: 492.58
• MDL number: MFCD34166232
• UNSPSC 코드: 41116105
• NACRES: NA.22

속성

• ligand: A1V1PF2
• Quality Level: 100
• 분석: ≥95%
• 양식: powder
• 반응 적합성: reagent type: ligand
• 작용기: amine
• 저장 온도: 2-8°C
• SMILES string: N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O)C
• InChI key: VMRCYJZQDCYTJO-MVJPYGJCSA-N

설명

애플리케이션

A1V1PF2-OEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V1PF2-OEt is also available as BocA1V1PF2 (917478).

A1V1PF2-OEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here: Browse our full synthesis offering here for streamlining SNIPER and PROTAC^® degrader libraries: Degrader Building Blocks

917427 A1V1PF2-OEt-C₆-NH₂ hydrochloride
917672 A1V1PF2-OEt-C₁₀-NH₂ hydrochloride
917923 A1V1PF2-OEt-PEG₁-NH₂ hydrochloride
916676 A1V1PF2-OEt-PEG₃-NH₂ hydrochloride

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

기타 정보

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable