901494

N-Methylated pomalidomide

≥98%

• 동의어(들): 4-Amino-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, E3 Ligase ligand methylated negative control, Ligand for PROTAC^® research
• 실험식(Hill 표기법): C₁₄H₁₃N₃O₄
• CAS Number: 1352827-50-9
• Molecular Weight: 287.27
• MDL number: MFCD31703382
• UNSPSC 코드: 12352101
• NACRES: NA.22

속성

• ligand: N-Methylated Pomalidomide
• Quality Level: 100
• 분석: ≥98%
• 양식: powder or crystals
• 반응 적합성: reagent type: ligand
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• SMILES string: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3N)=O)N(C)C1=O
• InChI: 1S/C14H13N3O4/c1-16-10(18)6-5-9(13(16)20)17-12(19)7-3-2-4-8(15)11(7)14(17)21/h2-4,9H,5-6,15H2,1H3
• InChI key: YSWQOCGODHPKED-UHFFFAOYSA-N

설명

애플리케이션

N-Methylated pomalidomide is a ligand used as a negative control for pomalidomide (P0018) in the recruitment of the Cereblon (CRBN) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.

기타 정보

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable