929476

N-Acetyl-S-(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-L-cysteine

≥95%

• 동의어(들): p-Fluorobenzylguanine ligand, AUTAC ligand, FBnG
• 실험식(Hill 표기법): C₁₇H₁₇FN₆O₄S
• CAS Number: 2241669-86-1
• Molecular Weight: 420.42
• MDL number: MFCD32670504
• UNSPSC 코드: 12352209
• NACRES: NA.21

속성

• Quality Level: 100
• 분석: ≥95%
• 양식: powder or chunks
• 반응 적합성: reagent type: ligand
• 저장 온도: 2-8°C
• SMILES string: O=C1NC(N)=NC2=C1N=C(SC[C@@H](C(O)=O)NC(C)=O)N2CC3=CC=C(C=C3)F

설명

애플리케이션

N-acetyl-S-(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-L-cysteine is a p-fluorobenzylguanine (FBnG) based ligand used to initiate selective autophagy as a strategy for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.

Related Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Browse our growing synthesis and research tools: Protein Degrader Building Blocks

기타 정보

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable