930687

2,6-Piperidinedione, 3-[(3-aminophenyl)amino] hydrochloride

≥95%

• 동의어(들): 3-((3-Aminophenyl)amino)piperidine-2,6-dione hydrochloride
• 실험식(Hill 표기법): C₁₁H₁₃N₃O₂ · xHCl
• CAS Number: 2446932-26-7
• Molecular Weight: 219.24 (free base basis)
• MDL number: MFCD34704581
• UNSPSC 코드: 12352200
• NACRES: NA.28

속성

• Quality Level: 100
• 분석: ≥95%
• 반응 적합성: reagent type: ligand
• 작용기: amine
• 저장 온도: 2-8°C
• SMILES string: O=C1NC(C(CC1)NC2=CC(N)=CC=C2)=O.[xHCl]

설명

애플리케이션

2,6-Piperidinedione, 3-[(3-aminophenyl)amino] hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable