699852P

3D-PHAD^™

Avanti Research^™ - A Croda Brand

• 동의어(들): Monophosphoryl 3-Deacyl Lipid A (Synthetic) Pat No. 9,241,988
• 실험식(Hill 표기법): C₈₂H₁₅₈N₃O₂₀P
• CAS Number: 1699735-79-9
• Molecular Weight: 1537.11
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (HPLC)
• 양식: powder
• 포장: pkg of 1 × 1 mg (699852P-1mg); pkg of 1 × 5 mg (699852P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 응용 분야: vaccine development
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+]
• InChI: 1S/C82H155N2O20P.H3N/c1-6-11-16-21-26-31-33-38-43-48-53-58-72(89)99-66(56-51-46-41-36-29-24-19-14-9-4)61-71(88)84-76-80(103-74(91)62-67(57-52-47-42-37-30-25-20-15-10-5)100-73(90)59-54-49-44-39-34-32-27-22-17-12-7-2)79(104-105(95,96)97)68(63-85)102-82(76)9
• InChI key: XERJCJBCCDONJL-WOBTUNBLSA-N

설명

일반 설명

Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD^™), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.

애플리케이션

3D-PHAD^™ has been used:

• as a synthetic adjuvant for respiratory syncytial virus (RSV) vaccine
• as a synthetic adjuvant to prepare hepatitis B virus (HBV) and virus-like particles (VLP)-based human papillomavirus (HPV) vaccines
• in liposome preparation for the generation of army liposome formulation (ALF) for human immunodeficiency (HIV) gp140 antigen immunization studies in mice.

생화학적/생리학적 작용

3-deacyl-phosphorylated hexa-acyl disaccharide (3D-PHAD^™) is derived from monophosphoryl lipid A. It is amphiphilic and associates with the virosomal membranes.

특징 및 장점

The highly pure MPLA analog, 3D-PHAD^™, provides a homogeneous synthetic equivalent for the 3-deacylated MPLA derived from bacterial LPS. 3D-PHAD^™ is less pyrogenic than its bacterial-derived mimic while eliciting a comparable response to other MPLA analogs.

포장

2 mL Amber Glass Crimp Cap Vial (699852P-1mg)

2 mL Amber Glass Crimp Cap Vial (699852P-5mg)

기타 정보

For R&D use only. Not for drug, household, or other uses.

법적 정보

3D-PHAD is a trademark of Avanti Polar Lipids, LLC

Avanti Research is a trademark of Avanti Polar Lipids, LLC

PHAD is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids