700044P

7β-hydroxycholesterol-d7

Avanti Research^™ - A Croda Brand

• 동의어(들): cholest-5-ene-3b,7b-diol(d7)
• 실험식(Hill 표기법): C₂₇H₃₉O₂D₇
• CAS Number: 349553-97-5
• Molecular Weight: 409.70
• MDL number: MFCD03427682
• UNSPSC 코드: 12352100
• NACRES: NA.25

속성

• 설명: cholest-5-en-3β,7β-diol-d7
• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 1 mg (700044P-1mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 배송 상태: dry ice
• 저장 온도: −20°C

설명

일반 설명

7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol. 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.

애플리케이션

7β-hydroxycholesterol-d7 has been used:

• as cholesterol oxidation product for mass spectroscopy analysis
• as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis
• as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry
• as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification

생화학적/생리학적 작용

7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.

포장

5 mL Amber Glass Screw Cap Vial (700044P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids