700060P

desmosterol

Avanti Research^™ - A Croda Brand

• 동의어(들): 24-dehydrocholesterol; 5,24-cholestadien-3β-ol; 110798
• 실험식(Hill 표기법): C₂₇H₄₄O
• CAS Number: 313-04-2
• Molecular Weight: 384.64
• MDL number: MFCD00056432
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 설명: 3β-hydroxy-5,24-cholestadiene
• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 10 mg (700060P-10mg); pkg of 1 × 5 mg (700060P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCC=C(C)C)C)(CC3)C)CC=C2C1)C
• InChI: 1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChI key: AVSXSVCZWQODGV-DPAQBDIFSA-N

설명

일반 설명

Desmosterol lacks a double bond between C24 and C25 compared to cholesterol. It is present in the membrane of spermatozoa and astrocytes and is the major brain sterol.

애플리케이션

Desmosterol has been used as a sterol to test its interaction with human protein Mincle and as an internal standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). It may be used as in the preparation of lipid monolayers.

생화학적/생리학적 작용

Desmosterol is a precursor of cholesterol in the Bloch pathway and the enzyme 24-dehydrocholesterol reductase catalyzes this step. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. Desmosterol is a liver X receptor (LXR) agonist . It is a potential therapeutic target for treating the neurodegenerative disorder. Desmosterol regulates inflammatory signaling in macrophages.

포장

5 mL Amber Glass Screw Cap Vial (700060P-10mg)

5 mL Amber Glass Screw Cap Vial (700060P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable