700086P

DHEA sulfate

Avanti Research^™ - A Croda Brand

• 동의어(들): DHEA sulfate; DHEA; DHEA-S; 3β-hydroxy-5-androsten-17-one 3-sulfate (sodium salt); 5-androsten-3β-ol-17-one sulfate (sodium salt Prasterone sulfate (sodium salt)
• 실험식(Hill 표기법): C₁₉H₂₇NaO₅S
• CAS Number: 651-48-9
• Molecular Weight: 390.47
• MDL number: MFCD00242651
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 설명: Dehydroepiandrosterone sulfate (sodium salt)
• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 10 mg (700086P-10mg); pkg of 1 × 25 mg (700086P-25mg); pkg of 1 × 50 mg (700086P-50mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [S](=O)(=O)(O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@](CC3)(C(=O)CC4)C)CC=C2C1)C)O
• InChI: 1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1
• InChI key: CZWCKYRVOZZJNM-USOAJAOKSA-N

설명

일반 설명

DHEA sulfate is a metabolite of dehydroepiandrosterone (DHEA) produced by the addition of a sulfate group, catalyzed by the sulfotransferase enzymes SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. DHEA sulfate can also be back-converted to DHEA through the action of steroid sulfatase.

Dehydroepiandrosterone (DHEA) sulfate (DHEAS) is an adrenal steroid and is present in abundance in humans. It is the sulfate ester of DHAE and is synthesized by the adrenal glands and the gonads. DHEAS is produced in the zona reticularis.

애플리케이션

DHEA sulfate has been used:

• as a sulfated steroid in chemotaxis assay of bone-marrow (BM) neutrophil and also to test its inhibitory effect on the Rac-specific guanine nucleotide exchange factor (Rac GEF)
• as an internal standard in mass spectrometry
• as a synthetic lipid standard for spiking low-density lipoprotein (LDL) samples for liquid chromatography-mass spectrometry analysis (LC-MS)

생화학적/생리학적 작용

Dehydroepiandrosterone (DHEA) sulfate (DHEAS) regulates the synthesis of catecholamines. It modulates neurotransmitter receptors including the γ-aminobutyric acid type A (GABAA) and the N-methyl-D -aspartate (NMDA) receptors. Low levels of DHAES in brain is observed in Alzheimer′s disease (AD) patients.

포장

5 mL Amber Glass Screw Cap Vial (700086P-10mg)

5 mL Amber Glass Screw Cap Vial (700086P-25mg)

5 mL Amber Glass Screw Cap Vial (700086P-50mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids