548000

1-Pyrrolidinecarbodithioic Acid, Ammonium Salt

Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.

• 동의어(들): 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt, APDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄
• 실험식(Hill 표기법): C₅H₁₂N₂S₂
• CAS Number: 5108-96-3
• Molecular Weight: 164.29
• MDL number: MFCD00012720
• UNSPSC 코드: 12352106
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (titration)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: water: 1 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [S-]C(=S)N1CCCC1.[N+H4]
• InChI: 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
• InChI key: MDDIUTVUBYEEEM-UHFFFAOYSA-N

설명

일반 설명

Cell permeable. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells. Inhibits NF-κB activation and HIV replication in lymphocytes.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Induction of nitric oxide synthase activity in rat alveolar macrophages

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Irritant (B)

재구성

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.







From Catalog:

Desc. Field- added "cell-permeable"

기타 정보

Tsai, J.C., et al. 1996. J. Biol. Chem.271, 3667.
Pan, Z., et al. 1995. J. Biol. Chem.270, 7787.
Bessho, R., et al. 1994. Biochem. Pharmacol.48, 1883.
Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun.191, 1301.
Schreck, R., et al. 1992. J. Exp. Med.175, 1181.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable