681629

W-7, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 µM).

• 동의어(들): W-7, Hydrochloride, N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl
• 실험식(Hill 표기법): C₁₆H₂₁ClN₂O₂S · xHCl
• CAS Number: 61714-27-0
• Molecular Weight: 340.87 (free base basis)
• MDL number: MFCD00012559
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 설명: RTECS - QK0786000
• 분석: ≥98% (TLC)
• 양식: crystalline solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: off-white
• solubility: DMSO: 5 mg/mL; DMF: soluble; warm ethanol: soluble
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [S](=O)(=O)(NCCCCCCN)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]
• InChI: 1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H
• InChI key: OMMOSRLIFSCDBL-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 µM) and myosin light chain kinase (IC₅₀ = 51 µM).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Myosin light chain kinase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 51 µM inhibiting myosin light chain kinase; 28 µM inhibiting Ca2+-calmodulin-dependent phosphodiesterase

경고

Toxicity: Standard Handling (A)

기타 정보

Caulfield, M.P., et al. 1991. Neurosci. Lett.125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther.251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem.96, 1721.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable