MABT75

Anti-Titin (NT/Z-domain) Antibody, clone 17D11.1

clone 17D11.1, from mouse

• 동의어(들): Titin, Connectin, Rhabdomyosarcoma antigen MU-RMS-40.14
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 17D11.1, monoclonal
• 종 반응성: human, mouse
• 기술: immunohistochemistry: suitable (paraffin); western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_596870
• UniProt 수납 번호: Q8WZ42

설명

일반 설명

Titin is a large complex protein containing over one hundred IgG-like and fibronectin type-III domains, in addition to multiple Kelch, RCC1, TPR, and WD repeats. It is a member of the CAMK Ser/Thr protein kinase family and also possesses a protein kinase domain, which is involved in controlling gene expression and protein turnover in muscle tissues. Titin also functions as a sensor to mediate appropriate cellular responses to mechanical stress. In striated muscle tissue, titin regulates the length of the sarcomere by integrating myosin and actin filaments at the Z-disk and M-band, and facilitates the elasticity of the sarcomere. Titin also regulates sarcomere assembly and functions as central hub in signal transduction pathways. Defects in Titin may contribute to various forms of cardiomyopathy.

면역원

GST-tagged recombinant protein corresponding to human Titin.

애플리케이션

Anti-Titin (N-terminal/Z-domain) Antibody, clone 17D11.1 is an antibody against Titin (N-terminal/Z-domain) for use in Western Blotting, IHC(P).

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

품질

Evaluated by Immunohistochemistry in human and mouse cardiac muscle tissues.

Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected Titin in human and mouse cardiac muscle tissues.

표적 설명

38 kDa calculated

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Human and mouse cardiac muscle tissues

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable