16758

Poloxamer 407

purified, non-ionic

• 동의어(들): Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
• CAS Number: 9003-11-6
• MDL number: MFCD00082049
• UNSPSC 코드: 12352104
• NACRES: NA.25

속성

• Quality Level: 100
• 양식: powder
• 품질: purified
• 불순물: ≤1.0% water
• pH: 5.0-7.5
• solubility: soluble, clear, colorless
• 양이온 미량물: Al: ≤5 mg/kg; As: ≤0.05 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤50 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤1000 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• UV 흡수: λ: 260 nm A_max: ≤0.3; λ: 280 nm A_max: ≤0..2
• 적합성: no residue for filter test
• 저장 온도: 2-8°C
• SMILES string: O2C(C2)C.O1CC1
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• InChI key: RVGRUAULSDPKGF-UHFFFAOYSA-N

설명

일반 설명

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

애플리케이션

Poloxamer 407 has been used:

• as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
• for VLDL secretion assay in mice
• to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

생화학적/생리학적 작용

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)