19176

DL-Buthionine-sulfoximine

≥99.0% (TLC)

• 동의어(들): DL-Buthionine (S,R)-sulfoximine, BSO, Buthionine sulfoximine, Butionine sulfoximine
• 실험식(Hill 표기법): C₈H₁₈N₂O₃S
• CAS Number: 5072-26-4
• Molecular Weight: 222.31
• Beilstein: 2367136
• MDL number: MFCD00070309
• UNSPSC 코드: 12352202
• PubChem Substance ID: 57647786
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• Quality Level: 100
• 분석: ≥99.0% (TLC)
• 양식: powder or crystals
• mp: 215 °C
• solubility: H₂O: 50 mg/mL, clear to almost clear, colorless
• 저장 온도: 2-8°C
• SMILES string: CCCCS(=N)(=O)CCC(N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
• InChI key: KJQFBVYMGADDTQ-UHFFFAOYSA-N

설명

애플리케이션

DL-Buthionine-sulfoximine is suitable for use to:

• examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
• investigate the effect of BSO on development of bovine embryos
• inhibit GSH in several studies
• investigate the effect of GSH synthesis on oocyte maturation

It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

생화학적/생리학적 작용

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

기타 정보

Depletes glutathionine in isolated cells

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves