B2515

L-Buthionine-sulfoximine

≥97% (TLC)

• 동의어(들): L-BSO
• 실험식(Hill 표기법): C₈H₁₈N₂O₃S
• CAS Number: 83730-53-4
• Molecular Weight: 222.31
• Beilstein: 2367136
• MDL number: MFCD00067000
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24278263
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥97% (TLC)
• 양식: powder
• mp: 224-226 °C
• solubility: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: CCCCS(=N)(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
• InChI key: KJQFBVYMGADDTQ-CVSPRKDYSA-N
• 유전자 정보: human ... GCLC(2729), GCLM(2730)

설명

애플리케이션

L-Buthionine-sulfoximine has been used:

• as a selective activator for the induction of ferroptosis in rat apoptotic cells
• as an inhibitor of γ-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barley
• as a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1β expression in murine alveolar macrophages

Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

생화학적/생리학적 작용

Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)