30432

Dansylcadaverine

BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

• 동의어(들): N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide, N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine, Monodansyl cadaverine
• 실험식(Hill 표기법): C₁₇H₂₅N₃O₂S
• CAS Number: 10121-91-2
• Molecular Weight: 335.46
• Beilstein: 2951070
• EC Number: 233-326-9
• MDL number: MFCD00042704
• UNSPSC 코드: 12352108
• PubChem Substance ID: 57648439
• NACRES: NA.32

속성

• 제품 라인: BioReagent
• Quality Level: 100
• 분석: ≥99.0% (HPLC)
• mp: 137-140 °C
• 형광: λ_ex 335 nm; λ_em 518 nm in methanol; λ_ex 338 nm; λ_em 500 nm (Reaction product)
• 적합성: suitable for fluorescence
• 저장 온도: −20°C
• SMILES string: CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
• InChI: 1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
• InChI key: MLEBFEHOJICQQS-UHFFFAOYSA-N

설명

애플리케이션

Dansylcadaverine (MDC), an autofluorescent dye, is used to monitor autophagy. MDC accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

생화학적/생리학적 작용

Inhibitor of the fibrin-stabilizing fator; Inhibitor of epidermal growth factor (EGF) internalization; Fluorescent substrate for the assay of transamidating enzymes.

The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

air sensitive, handled under inert gas

기타 정보

Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves