A2478

APHA Compound 8

solid, ≥98% (HPLC)

• 동의어(들): 3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
• 실험식(Hill 표기법): C₁₆H₁₆N₂O₃
• CAS Number: 676599-90-9
• Molecular Weight: 284.31
• MDL number: MFCD29074969
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329770785
• NACRES: NA.77

속성

• Product Name: APHA Compound 8, ≥98% (HPLC), solid
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: Cn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2
• InChI: 1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+
• InChI key: UFQOXIMRSMFQRI-BQYQJAHWSA-N

설명

생화학적/생리학적 작용

HDAC (histone deacetylase) inhibitor.

One of a class of aroyl pyrrole hydroxy amide (APHA) compounds showing histone deacetylase (HDAC) inhibition, Compound 8 is the most potent and HDAC class I-selective.

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H317,H318
• 예방조치 성명서: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves