A4142

Azaserine

≥98% (TLC)

• 동의어(들): O-Diazoacetyl-L-serine
• 실험식(Hill 표기법): C₅H₇N₃O₄
• CAS Number: 115-02-6
• Molecular Weight: 173.13
• Beilstein: 1726602
• EC Number: 204-061-6
• MDL number: MFCD00036802
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24890830
• NACRES: NA.26

속성

• Quality Level: 100
• 분석: ≥98% (TLC)
• 양식: powder
• 색상: off-white to yellow-green
• 항생제 활성 스펙트럼: fungi
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C
• SMILES string: N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
• InChI: 1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1
• InChI key: MZZGOOYMKKIOOX-VKHMYHEASA-N

설명

일반 설명

Chemical structure: amino acid derivatives

애플리케이션

Used in cell culture for the selection of HGPRT revertants.

생화학적/생리학적 작용

Azaserine is an antibiotic and antifungal; it may also act as a tumor inducer. It is a structural analog of glutamine and competes with glutamine in binding to enzymes involved in purine biosynthesis. Azaserine inhibits purine biosynthesis by covalently reacting with cysteine residues in the enzyme active sites, such as in formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase. Azaserine can induce DNA damage via the formation of carboxymethylated bases and O⁶-methylguanine. Secretion of exo-1,3-β-glucanase and germ-tube formation of Candida albicans were inhibited by azaserine.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H351
• 예방조치 성명서: P201 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges