A6719

ω-Agatoxin IVA

≥90% (HPLC)

• 동의어(들): SNX 290
• 실험식(Hill 표기법): C₂₁₇H₃₆₀N₆₈O₆₀S₁₀
• CAS Number: 145017-83-0
• Molecular Weight: 5202.25
• MDL number: MFCD00165055
• UNSPSC 코드: 12352200
• NACRES: NA.28

속성

• Quality Level: 200
• 분석: ≥90% (HPLC)
• 양식: powder
• 응용 분야: metabolomics; vitamins, nutraceuticals, and natural products
• 저장 온도: −20°C
• 유전자 정보: human ... CACNA1A(773) ; mouse ... CACNA1A(12286) ; rat ... CACNA1A(25398)

설명

Amino Acid Sequence

Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala [Disulfide bridge: 4-20, 12-25, 19-36, 27-34]

일반 설명

CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene codes for the α1 subunit of neuronal CaV2.1 (P/Q-type) voltage-gated calcium channels. It is expressed throughout the central nervous system (CNS). CACNA1A gene is located on human chromosome 19p13.

애플리케이션

ω-Agatoxin IVA has been used in the manipulation of calcium influx. It has also been used in the study to characterize the spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays.

생화학적/생리학적 작용

Mutations in the CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene is responsible for episodic ataxia 2, familial hemiplegic migraine type 1 (FHM1) and spinocerebellar ataxia type 6 (SCA6).

Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels.

특징 및 장점

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable