A9210

Annexin V FITC Conjugate from human placenta

• 동의어(들): Annexin V, Calphosbindin I, Lipocortin V, PAP-1
• UNSPSC 코드: 41106305
• NACRES: NA.32

속성

• 양식: buffered aqueous solution
• Quality Level: 300
• 라벨링 범위: 1-2 mol FITC per mol annexin V
• UniProt 수납 번호: P08758
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 유전자 정보: human ... ANXA5(308)

설명

애플리케이션

For detection of apoptotic cells by flow cytometry or fluorescence microscopy.

생화학적/생리학적 작용

Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium.

Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium. The cellular changes involved in the apoptotic process include loss of phospholipid asymmetry during the early stages. This phenomenon is universal and is not limited to stimulus or to mammalian cells, but also occurs in insect and plant cells. In living cells, phosphatidylserine is transported to the inside of the lipid bilayer by the Mg²⁺ATP dependent enzyme, aminophospholipid translocase. At the onset of apoptosis, phosphatidylserine becomes translocated to the external surface of the cell membrane. Since the movement of phosphatidylserine from the internal membrane surface to the external surface is an early indicator of apoptosis, annexin V and its conjugates that interact strongly and specifically with phosphatidylserine may be used to detect apoptosis. Annexin V conjugates can be used to detect apoptotic cells significantly earlier than DNA-based assays. Fluorescent dye labeled annexin V have applications in flow cytometry, fluorescence microscopy, and laser scanning cytometry.

포장

Package size based on protein content

물리적 형태

Solution in 50 mM Tris-HCl, pH 7.5, containing 100 mM NaCl.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable