B6684

Rp-8-Bromo-β-phenyl-1,N²-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt

≥98% (HPLC), powder

• 동의어(들): Rp-β-Phenyl-1,N²-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium salt, Rp-8-Br-PET-cGMPS
• 실험식(Hill 표기법): C₁₈H₁₄BrN₅NaO₆PS
• CAS Number: 185246-32-6
• Molecular Weight: 562.27
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24724424
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 효능: 30 nM K_i
• 색상: white to beige
• mp: 240-300 °C (lit.)
• solubility: H₂O: 15 mg/mL at ≤60 °C
• 저장 온도: −20°C
• SMILES string: O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6
• InChI: 1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1
• InChI key: SVMPQLHYWRTQCX-DBHVCDLJSA-M

설명

생화학적/생리학적 작용

Rp-8-Br-PET-cGMPS is a metabolically stable, competitive inhibitor of both PKG I (K_i = 30 nM) and PKG II. Blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 micromoles).

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (K_i = 30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 micromoles).

특징 및 장점

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

법적 정보

U.S. Patent 5,625,056, DE Patent 4,217,679.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)