B8041

Biglycan from bovine articular cartilage

essentially salt-free, lyophilized powder

• MDL number: MFCD00676525
• UNSPSC 코드: 12352202
• NACRES: NA.75

속성

• 생물학적 소스: bovine articular cartilage
• Quality Level: 200
• 양식: essentially salt-free, lyophilized powder
• 분자량: 200-350 kDa
• 포장: glass bottle of 0.5 mg
• 기술: cell culture | mammalian: suitable
• solubility: water: soluble ≥2.00 mg/mL, clear, colorless
• UniProt 수납 번호: P21809
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: cow ... BGN(280733)

설명

일반 설명

proteoglycan consisting of a 45 kDa core protein and two chrondroitin/dermatan sulfate glycosaminoglycan chains

생화학적/생리학적 작용

Biglycan interacts with collagen type I and II, fibronectin and TGF-ß. In a low ionic strength (less than 3 mM phosphate) buffer, Biglycan binds more strongly to collagen type I. At higher ionic strengths, Biglycan will instead increase the inhibition effect of TGF-ß on osteoclast proliferation at a concentration of 4-20 mg/mL. It also functions to prevent the attachment of CHO cells to fibronectin, with a 50% inhibition at 17-21 mg/mL. As an extracellular component, Biglycan binds TGF-β 1, facilitates bone mineralization and supports osteoblast differentiation thru BMP-4 binding.

성분

Biglycan is a 200-350 kDa proteoglycan consisting of a 45 kDa core protein and two chondroitin/dermatan sulfate glycosaminoglycan chains.

주의사항

Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly.

제조 메모

This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and 0.2 μm filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)