A1960

Aggrecan from bovine articular cartilage

lyophilized powder

• 동의어(들): Aggrecan Protein
• MDL number: MFCD00676441
• UNSPSC 코드: 12352202
• NACRES: NA.75

속성

• 생물학적 소스: bovine articular cartilage
• Quality Level: 200
• 양식: lyophilized powder
• 포장: glass bottle of 1 mg
• 기술: cell culture | mammalian: suitable
• 불순물: salt, essentially free
• 색상: white
• solubility: H₂O: 2 mg/mL
• UniProt 수납 번호: P13608
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: cow ... AGC1(280985)

설명

애플리케이션

Aggrecan is a critical component for cartilage structure and the function of joints. Its synthesis and degradation are being studied for their roles in cartilage deterioration during joint injury disease and aging.

생화학적/생리학적 작용

This molecule produces a rigid, reversibly deformable gel that resists compression. It combines with hyaluronic acid to form very large macromolecular complexes that have an increased hydrohynamic volume and a significant increase (30-40%) in the relative viscosity of the solution.

성분

Aggrecan is a major structural proteoglycan of the cartilage extracellular matrix. It is a large proteoglycan, with a molecular weight greater than 2,500 kDa composed of approximately 100-150 glycosaminoglycan chains attached to a core protein. The majority of these glycosaminoglycan chains are chondroitin/dermatan sulfate. Aggrecan contains three globular domains, G1, G2, and G3, which are involved in aggregation and hylauronan binding, cell adhesion and chondrycte apoptosis.

주의사항

Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly.

제조 메모

This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and 0.2 μm filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)