C1728

Anti-Calcium Channel (α_1D Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 동의어(들): Anti-CACH3, Anti-CACN4, Anti-CACNL1A2, Anti-CCHL1A2, Anti-Cav1.3, Anti-PASNA, Anti-SANDD
• MDL number: MFCD02095953
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: lyophilized powder
• 종 반응성: mouse, rat
• 기술: immunocytochemistry: 1:30-1:150; immunoprecipitation (IP): suitable; western blot (chemiluminescent): 1:100-1:200
• UniProt 수납 번호: Q99246
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CACNA1D(776) ; mouse ... Cacna1d(12289) ; rat ... Cacna1d(29716)

설명

면역원

synthetic peptide corresponding to amino acids 859-875 of rat α_1D (Accession P27732). This epitope is highly conserved in human and hamster.

애플리케이션

Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for the following applications:

• immunocytochemistry at a dilution of 1:30-1:150
• immunoprecipitation
• western blot (chemiluminescent) at a dilution of 1:100-1:200

생화학적/생리학적 작용

Ca_v1.3 also known as the calcium channel, voltage-dependent, L type, α1D subunit (CACNA1D), is a human gene. It responds more sensitively to depolarization than those of Ca_v1.2 or Ca_v3.1. Ca_v1.3 is required for proper hearing as well as sinoatrial node and brain function. It undergoes extensive alternative splicing. Alternative splicing in the C terminus and drastically modifies gating properties of the channel. The L-type calcium channel Ca_v1.3 is important in human glucose-induced insulin secretion and common variants in CACNA1D may contribute to type 2 diabetes.

물리적 형태

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable