C2997

Cytosporone B

≥98% (HPLC), powder, nuclear receptor Nur77 agonist

• 동의어(들): 3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester, Csn-B, Csn-B; 3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester
• 실험식(Hill 표기법): C₁₈H₂₆O₅
• CAS Number: 321661-62-5
• Molecular Weight: 322.40
• MDL number: MFCD12912406
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329775016
• NACRES: NA.77

속성

• Product Name: Cytosporone B, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to off-white
• solubility: DMSO: >20 mg/mL
• 저장 온도: −20°C
• SMILES string: CCCCCCCC(=O)c1c(O)cc(O)cc1CC(=O)OCC
• InChI: 1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
• InChI key: UVVWQQKSNZLUQA-UHFFFAOYSA-N

설명

애플리케이션

Cytosporone B has been used:

• as a positive control and NR4A1 agonist in NR4A1 reporter gene assay
• for Nr4a1 activation
• to treat OVX mice and study its effect on migration of osteoclast precursor

생화학적/생리학적 작용

Cytosporone B (Csn-B) is the first naturally occurring agonist for nuclear orphan receptor Nur77.

Cytosporone B (Csn-B) is the first naturally occurring agonist for nuclear orphan receptor Nur77. It binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities.

Nur77 is a nuclear receptor/transcription factor. A physiological ligand for Nur77 is as yet unknown, but there is increasing interest in Nur77 because of its known activities. Translocation of Nur77 from the nucleus to mitochondria initiates cell apoptosis, making it a potential target for cancer treatment. Nur77 is also involved in glucose homeostasis; it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.

Cytosporone B is a fungal metabolite closely related to phomposin C. It is the first known agonist for the nuclear orphan receptor Nur77. It binds with high affinity (IC₅₀ = 0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities.

Nur77 is a nuclear receptor/transcription factor with no known physiological ligand, but there is increasing interest in Nur77 because of its known activities. Translocation of Nur77 from the nucleus to mitochondria initiates apoptosis, making it a potential target for cancer chemotherapy. Nur77 also induces genes involved in gluconeogenesis. Csn-B activates the Nur77 translocation to mitochondria to induce apoptosis, inhibiting cancer cell proliferation and tumor growth.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable