C6499

CTB

≥98% (HPLC)

• 동의어(들): CTPB, N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide
• 실험식(Hill 표기법): C₁₆H₁₃ClF₃NO₂
• CAS Number: 451491-47-7
• Molecular Weight: 343.73
• MDL number: MFCD02356522
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to off-white
• solubility: DMSO: >10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
• InChI key: YDXZSNHARVUYNM-UHFFFAOYSA-N

설명

일반 설명

CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.

애플리케이션

CTB has been used to study its apoptotic effects on P53 protein acetylation.

생화학적/생리학적 작용

CBP (CREB binding protein)/p300) histone acetyltransferases (HATs) activator; p300 HAT activator.

CTPB was a first known small molecular activator of histone acetyltransferase p300. CTB is a simplified analog of CTPB with comparable or higher activity. The compound activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein.

Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2