M2449

MB-3

≥95% (HPLC)

• 동의어(들): γ-butyrolactone, Butyrolactone 3, (2R,3S)-rel-4-Methylene-5-oxo-2-propyltetrahydrofuran-3-carboxylic acid
• 실험식(Hill 표기법): C₉H₁₂O₄
• Molecular Weight: 184.19
• MDL number: MFCD08702690
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329817942
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: powder
• 색상: white to off-white
• solubility: H₂O: ≥10 mg/mL; DMSO: ≥20 mg/mL
• 저장 온도: −20°C
• SMILES string: CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
• InChI: 1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1
• InChI key: SRQUTZJZABSZRQ-RQJHMYQMSA-N

설명

애플리케이션

MB-3 has been used as a general control non-repressible 5 (GCN5) inhibitor:

• to study its effects on lamin A/C-associated pY19-Cav-2-mediated histone H3 acetylations
• to analyze its effects on the growth of Arabidopsis thaliana seedlings
• to study its effects on craniofacial chondrocyte maturation

생화학적/생리학적 작용

MB-3 can modify the gene expression in murine embryonic stem cells as well as yeast. It hinders the acetyltransferase activity of general control non-repressible 5 (GCN5) by binding to acetyl CoA pocket present in GCN5.

MB-3 is a Gcn5 HAT (Histone Acetyltransferase) inhibitor; anti-inflammatory, anti-carcinogenic.

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable