C8739

Cyclin-Dependent Kinase 5 human

recombinant, expressed in E. coli BL21, 50-100 units/μg protein

• MDL number: MFCD06201997
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 재조합: expressed in E. coli BL21
• Quality Level: 200
• 양식: solution
• 특이 활성도: 50-100 units/μg protein
• 포장: vial of 300 units
• 배송 상태: dry ice
• 저장 온도: −70°C

설명

애플리케이션

Human cyclin-dependent kinase 5 has been used in a study to determine its 3′ untranslated region subunit 1 contains regulatory elements that affect transcript stability.

생화학적/생리학적 작용

CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.

단위 정의

One unit will phosphorylate 1.0 picomole of the peptide substrate histone H1^9-18 per minute at 30 °C at pH 7.4.

물리적 형태

Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)