D052

GBR 12909 dihydrochloride

solid, ≥98% (HPLC)

• 동의어(들): 1-(2-[bis(4-Fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
• 실험식(Hill 표기법): C₂₈H₃₂F₂N₂O · 2HCl
• CAS Number: 67469-78-7
• Molecular Weight: 523.49
• MDL number: MFCD00055193
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277909
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: desiccated
• 색상: white
• solubility: DMSO: >5 mg/mL (Solutions freshly prepared daily)
• SMILES string: Cl.Cl.Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4
• InChI: 1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
• InChI key: MIBSKSYCRFWIRU-UHFFFAOYSA-N
• 유전자 정보: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

설명

애플리케이션

GBR 12909 dihydrochloride has been used as a dopamine transporter (DAT) inhibitor:

• to study its effects on LPS-induced mRNA expression on the proinflammatory cytokines in the mouse striatum
• to study its effects on neurotransmitter release in zebrafish brain
• in DA uptake assay in mice striatal fraction

생화학적/생리학적 작용

GBR 12909 is a highly selective dopamine reuptake inhibitor with behavioral effects similar to cocaine.

GBR 12909 may show pharmacotherapeutic effects against cocaine addiction.

특징 및 장점

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)