D1064

Dihydrokainic acid

≥98% (HPLC), powder

• 동의어(들): 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid
• 실험식(Hill 표기법): C₁₀H₁₇NO₄
• CAS Number: 52497-36-6
• Molecular Weight: 215.25
• MDL number: MFCD03412037
• UNSPSC 코드: 12352106
• PubChem Substance ID: 24277981
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• solubility: H₂O: >10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
• InChI: 1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
• InChI key: JQPDCKOQOOQUSC-OOZYFLPDSA-N
• 유전자 정보: human ... SLC1A1(6505), SLC1A2(6506), SLC1A3(6507) ; rat ... Slc1a2(29482), Slc1a3(29483)

설명

애플리케이션

Dihydrokainic acid has been used as a glutamate transporter (GLT-1) inhibitor in the glutamate uptake assay of astrocytes and glial cells. It may be used as a GLT-1 inhibitor in Lateral habenula (LHb).

생화학적/생리학적 작용

Dihydrokainic acid is a selective GLT-1 glutamate transporter inhibitor; weak inhibitor of AMPA/kainate glutamic acid receptors at high concentrations.

Dihydrokainic acid is a selective inhibitor of the GLT-1 glutamate transporter. At higher concentrations, dihydrokainate is a weak inhibitor of AMPA/kainate glutamic acid receptors.

Dihydrokainic favors neuronal cell death. It modulates anxiety and depression behaviors.

특징 및 장점

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves